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Leishmaniasis, leishmania-4-638, leishmania-5-638, leishmania-6-638,…
Leishmaniasis
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Discovery
In November 1900, the Scottish pathologist "William Boog Leishman" (1865–1926) who served with the British Army in India, discovered ovoid bodies in smears taken post-mortem from the spleen of a soldier who died from emaciation and splenomegaly while stationed at "Dum Dum", a town near Calcutta.
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Classification
- Domain : Eukaryote
- Class : Kinetoplastea
- Order : Trypanosomatida
- Species : L. aethiopica , L .major , L .infantum , L.tropica , L . donovii , L.chagasi , L.. mexicana etc.,
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Life cycle
(1)The sandflies inject the Infective stage, promastigotes, during blood meals
(2) Promastigotes that reach the Puncture wound are phagocytized by macrophages
(3) and transform into amastigotes
(4) Amastigotes multiply in infected cells and affect different tissues, depending in part on the Leishmania species
(5).This originates the clinical manifestations of leishmaniasis.
(6) Sandflies become infected during blood meals on an infected host when they ingest macrophages infected with amastigotes.
(7).In the sandfly’s midgut, the parasites differentiate into promastigotes.
(8) which multiply and migrate to the proboscis (8
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Symptoms
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