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Leishmania donovania, Screenshot_20240303-131208 ), Screenshot_20240303…
Leishmania donovania
Characteristics
- Discovered by William Leishman and Donovan
- Mainly affect reticuloendothelial system.
- Host : human, dog and rodents.
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lab diagnosis
Blood count: WBC count
Peripheral blood film
Confirmatory test : Montenegro test
Treatment
- no specific vaccination
- Chemotherapy - sodium stibogluconate
Amphotericin B
Monomycin
Morphology
2 forms *amastigote
Amastigote
- Found in human
- 2 to 4 micrometre in diameter
- Single nucleus
- Blepharoplast and axoneme connected together.
- Non motile
Promastigote
- Long slender
- Length - 1.5 - 25. micrometre
- Breadth - 1.5 - 3.5 micrometre
- Axoneme extended outside
- Motile
- Found on guys of insects.
Pathogenesis
- fever, malaise, head ache.
- Anaemic condition
- WBC count become less
- Lymphadenopathy
- Hepatoadenopathy
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