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Toxoplasma gondii - Coggle Diagram
Toxoplasma gondii
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Morphology
Trophozoite
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Tissue cyst
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Cyst is oval ,10 - 20 um in size
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Oocyst
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infective oocyst is ingested, it releases
sporozoites in the intestine, which initiates infection
Life cycle
Enteric cycle
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Cat acquires infection by ingestion of tissue cysts in the
meat of rats and other animals or by faeces
The bradyzoites are released in the small intestine and
they undergo asexual multiplication and form merozoites
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Other merozoites transform into male and female
gametocytes and sexual cycle (gametogony) begins, with
the formation of microgamete and macrogamete.
macrogamete is fertilized by motile microgamete
resulting in the formation of an oocyst,
Exoenteric cycle
Sporozoites from the oocysts and bradyzoites from the
tissue cysts enter into the intestinal mucosa and multiply
asexually and tachyzoiles are formed
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Tachyzoites also spread to distant extraintestinal
organs like brain, eye, liver, spleen, lung and skeletal
muscles and form tissue cysts.
The dormant bradyzoites inside the cyst may be
reactivated in immune suppression causing renewed
infection in the host.
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Pathogenicity
lymphadenopathy;
Fever, headache, myalgia and splenomegaly are often
present.
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Treatment
Neonates with congenital infection are treated the oral
pyrimethamine (1 mg/ kg) daily and sulfadiazine (100 mg/
kg) with folinic acid for 1 year