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Leishmania donovani - Coggle Diagram
Leishmania donovani
INTRODUCTION
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Host - Human, Dog and Rodents
Named after 2 scientist in 1903 - Sir William Boog Leishman ( discovered it in the British soldier liver in 1900 and reported in 1903 as Dum- Dum fever ) and Sir Donovan discovered it in the spleen from a Chennai patient.
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MORPHOLOGY
Amastigote
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Blepharoplasty, Axoneme are connected together that is interior flagellum
Stained by Giemsa stain , cytoplasm - blue; Nucleus - Red
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LIFE CYCLE
In order to release the promastigotes by bitting the individual. 6 to 9 days for Amastigotes to promastigotes and release.
As soon as promastigotes enter into the host , the macrophages engulf it and the conversion to amastigotes takes place.
Reproduce by binary fission.Then, promastigotes migrate to the buccal cavity and then to proboscis.so, it stops the feeding of the insect.
It multiplies more in number , rupture of parasitized cells, carried in the circulation, invasion of other reticuloendothelial cells and multiples again.
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After it repeats for 2to 3 times, the patient become low in immunity.
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PATHOGENESIS
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Anemic condition, Pale skin
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Lab diagnosis
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Molecular methods - DAT, ELISA, PCR, Indirect fluorescent antibody.
Blood count - leucocyte count is 3000/μl of blood, after disease 1000/μl or below.
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TREATMENT
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Chemotherapy - Amphotericin B , Monomycin, Pentamidine, Aminosidine
