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Trypanosoma brucei images (14) - Coggle Diagram
Trypanosoma brucei
Introduction
First demonstrated by Bruce in horse and cattles in 1895
Forde (1902)- motile trypanosomes in blood of man suffering
Dutton- named trypanosoma gambiense
Klein - Development of parasite in vector tsetse fly
Morphology
Habitat - connective tissues
Blood
CNS
Trypomastigote forms
Long slender -motile
Short stumpy - without flagellum
Intermediate - Epimastigote form
Lifecycle
Invertebrate
After metacyclic trypomastigote transform into long slender trypomastigote
Multiply by binary fission
Taken to blood vessels and convert to short stumpy form
Vertebrate
Short stumpy form will convert into long slender in midgut
Epimastigote in salivary gland
Residing in salivary gland gets into metacyclic trypomastigote form
Pathogenicity
Parasitaemia in blood
African trypanosomiasis
Chance,lymph adenopathy
Winterbottom's sign
CNS- behavioural changes
Lab diagnosis
Wet count
Giemsa stain
Culture - wienman's medium
Csf examination- presence of mott cells
Serological techniques
ELISA
IFA
Molecular methods - pcr,dna assay,fish
Treatment
Suramin
Pentamidine
