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ANTI-TUBERCULAR DRUGS, Nitroimidazoles, 0- 2 week, C/I, Dose, 2- 24 week,…
ANTI-TUBERCULAR DRUGS
Older Drugs
Thioacetazone
Para aminosalicylic Acid (PAS)
Ethionamide
Newer Drugs
Block Mycobacterial ATP Synthase
Bedaquiline (BDQ)
Block mycolic acid synthesis
Delamanid
Pretomanid
Rifampicin
RNA Polymerase Inhibitor
Enzyme inducer
Causes drug failure (Nevirapine failure)
Isoniazid
DOC in the prophylaxis of TB/Latent TB infection
Mycolic Acid Synthesis Blocker
S/E
Decreased GABA and Decreased Heme
Pyrazinamide
Most Hepatotoxic Drug
Ethambutol
MOA
Blocks Arabinosyl Transferase
Decreased arabinogalactan
Decreased Cell Wall Synthesis
Regimen for a New Case or Previously treated
2 HRZE
Nitroimidazoles
0- 2 week
400 mg OD
C/I
Pregnancy and Lactation
Dose
Intermittent
2- 24 week
200 mg thrice a week
Note
Drug Resistant Tuberculosis
MDR TB
INH + Rifampicin(R) Resistance
Pre XDR TB
INH + Fluoroquinolone or second line injectables (SLI)
Polydrug Resistant TB
INH + Only 1st line drug
XDR- TB
INH + R + FQ + SLI
Monodrug Resistant TB
INH Resistance
(Cidal)
(Blocks Mycolic Acid Synthesis)
(Bacteriostatic Drug)
Blocks DHPS
(Bacteriostatic Drug)
2nd Line Drugs
First Line Drugs (HRZE)
(Continuous Phase for 4 months)
(Intensive Phase for 2 months)
4 HRE
+
200 mg OD
100 mg BD
(MOA)
(MOA)
H
R
Z
E
Cidal
(Ecxept Rifampicin Resistance)
