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LEISHMANIASIS - Coggle Diagram
LEISHMANIASIS
INTRODUCTION
Obligatory intracellular protozoa
genus leishmania
leishmania donovani
obligate intracellular parasite
transferred by vector - sandfly
habitat - reticulo endothelial systems
phlebotoma argentipus
named after Sir William boog leishman & Sir Donovan
Black fever - kala azar
TREATMENT
Amphotericin B deoxycholate
sodium antimony gluconate
sodium stibogluconate
meglumine antimoniate
metranidazole
MORPHOLOGY
Amastigate & Promastigate
Amastigate - Reticulo endothelial section
Promastigate - Vectors / insects
Amastigate morphology
2 to 4 micrometer diameter
oval shaped
nucleus is 1 micrometer diameter
Blepharoblast
Parabasal body
Blepharoblast & Axoneme are integrated and forms an interior flagella
non motile
food vacuole present
Giemsa stain
Promastigate morphology
Long linear shaped
15 to 25 micrometer in length
1.5 - 3.5 micrometer in breadth
nucleus 1 micrometer diameter
Axoneme extends outside as a free flagellum
Motile
Blepharoblast is present
Parabasal body
Food vacuole is present
present in vector
infectious form
PATHOGENESIS
Lymph adenopathy
Hepatomegaly
Hepatospleenomegaly
Anaemia
CLINICAL MANIFESTATION
Fever, malaise, headache
Prograssive enlargement of spleen, liver and lymph nodes
Anaemia
Leucopinia
Exaciation
LIFE CYCLE
