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Leishmania donavani images (13) - Coggle Diagram
Leishmania donavani 
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Discovery
Sir William Boog leishman in London, he observed in liver in 1900.
But he reported in 1903 from British soldier , he died of fever ( Dumdum fever) in Kolkata Dumdum
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Life cycle
Vertebrate host: man, dog, rodents
Invertebrate host: female sand fly ( Phlebotomus argentipes)
- Amastigote released from infected human bloods and suck by sandfly
- Amastigote converted to Promastigote in midgut of sandfly
- Reproduce by binary fission
- After multiply enormous, move to buccal cavity, finally reach to proboscis.
- Sandfly can release the Promastigote in human or rodents blood by biting
- After entering in to human or rodents it engulf by macrophage
- Again Promastigote convert to Amastigote and multiply
- After multiply , rupture and reach to another organs through blood circulation ; And reach to reticlo endothelial cells, again multiply and rupture
- It leads to lowering of Immunity
- If the infected person get bite by sandfly , amastigotes transfer to sandfly
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Amastigote
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Axoneme & Blepharoplast is connected together, both are interior flagella , non - motile
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Clinical manifestation
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Enlargement of spleen, liver, lymph nodes
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Lab diagnosis
Leukocyte count, it fall 3000ul to 1000 ul
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Immunological test: DAT, IFA, CIE
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Treatment
Chemotherapy- sodium stibogluconate; Meglumine antimoniate; pentamidine;Monomycin;paromomycin; Aminosidine; AmphotericinB ; Allopurino