Nucleotide are made up of 3 main parts, a phosphate group, a nucleotide group, and a pentose sugar. The phosphate group will be universal between RNA and DNA nuclkoetides but the pentose sugar does change. In DNA it will always be deoxyribose and in RNA it will always be ribose. The nitregenous base will either be C, G, A, and T and in RNA the T will be switched for U.