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Immune System - Coggle Diagram

- - - - Migrate to tissues
      - Phagocytize, release cytokines, present antigens
      - Secretory products such as hydrolytic enzymes, TNF-alpha,
        interleukins
- - - - Type I: Immediate
        (allergies)
        
        Known as allergy or atopic disorder
        
        Antigen (allergen) interacts with APC (antigen-
        presenting cell)
        
        B cells are activated and produce IgEs
        
        IgEs bind to mast cells
        
        Cause degranulation (release of chemicals from
        mast cells)
        
        Chemicals induce allergy symptoms
      - Type II: Cytotoxic
        
        Igs attack antigens on
        cell surface
        
        Antibody-mediated cell
        lysis results
        
        Blood transfusion reaction is an example of a type II hypersensitivity
      - Type III: Immune
        Complex
        
        Antigen-antibody complex deposited in tissues
        
        Also known as “immune
        complex”
        
        Tissue damage results
        
        May be systemic (lupus) or located (rheumatoid arthritis)
      - Type IV: Delayed
        
        T cell mediated
        
        Previous exposure to antigen primes the T cells
        
        T cell attack does not occur until days after
        initial exposure (delayed)
        
        Example: poison ivy, transplant rejection
        
        Mantoux test for tuberculosis demonstrates a
        Type IV hypersensitivity
  - - - Primary (congenital)
        
        Present at birth
      - Secondary (acquired)
        
        Develops due to infection, chemotherapy, immunosuppressive drugs, etc.