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Antifungal Agents - Coggle Diagram

- - - - Indications
        
        Dermatophyte infx
        
        tinea corporis (ringworm)
        
        Tiena pedis
        
        Cutaneous candidosis
        
        Tinea (pityriasis) veriscolor
    - - Indications
        
        Candidal vaginitis
        Canesten pessary
        
        Vulvitis balanitis
        Canesten cream
- - - - Indications
        
        Candidiasis
        
        Crytocococcsis
      - Pharmacokinetics
        
        Renal excretion
        
        t1/2 25-30hrs
        
        Wide distribution
        
        Good CSF penetration 🧠
      - Dose
        
        Acute/ recurrent vaginal candidiasis - 150mg PO single dose
        
        Mucosal / systemic candidiasis 50 mg
        
        Systemic infx 200mg-400mg
        
        Prevention of relapse of cryptococcal meningitis 100mg-200mg daily
      - Adverse Effects
        
        Nausea 🤢
        
        Headache 🤕
        
        Skin rash 🦒
        
        Abdominal pain
      - Interactions
        
        CYP450 3A4, 2C9, 2C19
    - - Indications
        
        Onychomycosis
        
        Systemic mycoses
        
        Pityriasis veriscolor
        
        Dermatophytoses
        
        Oral candidosis
        
        Vulvovaginal candidosis
      - Interactions
        
        Inhibits CYP 3A4
      - Side Effects
        
        Hepatotoxicity 🐄
        
        Hypertriglyceridaemia 🍔
        
        Hypokalaemia ⬇️🍌
- - - - Binds intracellular Microtubular Protein
      - Inhibits Mitosis
  - - - Convertd to 5-fluorouracil
      - Incorporated into fungal RNA inhibiting protein synthesis
    - - Used with Amphoteracin B
      - Crytococcus neoformans
      - Candida spp
    - - Bone Marrow suppression 🦴
      - Leukopenia :shield:
      - Thrombocytopaenia 🩸