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Myasthenic Drugs - Coggle Diagram
Myasthenic Drugs
AcHase Inhibitors
pyridostigmine
more effective that neostigmine
edrophonium
reversibly inhibits cholinesterase, used for diagnostic
neostigmine
stimulates nicotinic and muscarinic receptors
No CNS penetration
Adverse effects
DUMBBELLS
Diarrhea, urination, miosis, bronchospasm, bradycardia, emesis, lacrimation, sweating, salivation
physostigmine
crosses blood brain barrier
Immunosuppresants
prednisone
inhibits phospholipase A2, immunosuppresive
adverse effects: weight gain, muscle wasting, hyperglycemia, osteoporosis, hypokalemia, hypertension, infections
mycophenolate mofetil
inhibits purine synthesis of lymphocytes
AE: nausea, diarrhea
cyclosporine
binds to cyclophillin to inhibit calcineurin and IL-2 receptor production
AE: hypertension, and nephrotoxicity
tacrolimus
binds to FK, inhibits calcineurin, inhibits T-cell activation
AE: hyperglycemia, hypomagnesemia, tremor, and parasthesias
azathioprine
blocks nucleic acid synthesis
AE:bone marrow suppression
Antibody-based therapies
efgartigimod alfa
promotes degradation of autoIgG
rozanolixizumab
promotes lysosomal degradation of autoIgG
complement inhibitors
eculizumab
ravulizumab
amifampridine
blocks potassium channels -->prolonged depolarization of motor endplate