15.2 Nervous communication

Structure

Central nervous system

Brain

Spinal cord

Peripheral nervous system

Cranial and spinal nerves

Neurones

Sensory neurones

Transmit impulses from receptors to CNS

Relay neurones

Transmit impulses from sensory neurones to motor neurones

Motor neurones

Transmit impulses from CNS to effectors

Found only in CNS

Many branched dendrites provides large surface area for axon terminals of other neurones

Terminal branches have mitochondria and vesicles containing neurotransmitters

Cell body lies along axon

Cell body lies within CNS

Has synaptic endings instead of dendrites

Cytoplasm contains many mitochondria and extensive RER for protein synthesis

Myelin

Many axons are myelinated

Schwann cells wrap themselves around the axon, forming the myelin sheath

Myelin sheath is largely lipid-based

Gaps between Schwann cells are called Nodes of Ranvier

Resting potential

The difference in electrical potential between the inside and the outside of the axon

-70mV

Maintained by sodium-potassium pumps (3 sodium out, 2 potassium in)

Membrane is impermeable to ions, and voltage-gated channel proteins are closed

Action potential

Electric current used to stimulate the axon opens voltage-gated Na+ channels

Na+ enter, making the inside of the axon less negative, causing more voltage-gated channels to open

Positive feedback loop of depolarisation

Inside potential reaches +30mV

Action potential is only initiated if the threshold potential of -60 to -50mV is reached

All or nothing event

Na+ channels close, K+ channels open

Membrane is hyperpolarised, voltage-gated K+ channels close, K+ ions diffuse back into the axon to restore resting potential of -70mV

Travel along an axon

Action potential on an axon cell surface membrane triggers action potentials on either side of that point

Current flows in a local circuit due to differences in charge between site of action potential and adjacent areas

Action potentials only occur ahead as the area behind is still in the refractory period and the ion channels cannot reopen

Action potentials are discrete events

Minimum time between action potentials and therefore maximum frequency of impulses is limited by refractory period

Impulses are unidirectional

Carrying of information

Constant size

Constant speed of travel

Strong stimulus = high frequency of impulses, and more neurones carrying impulses

Type of stimulus is deduced by brain from position of the sensory neurone carrying the stimulus

Speed of conduction of impulses

Myelin speeds up rate of action potential travel

Thick axons transmit impulses faster, as they have a greater surface area over which diffusion of ions can occur

Saltatory conduction is faster than normal transmission

Myelin sheath is an insulator, and is impermeable to sodium and potassium ions

Action potentials can only occur at nodes of Ranvier

Receptors

Can be specialised cells that activate sensory neurones

Can simply be the end of a sensory neurone itself

Salt receptors in the taste buds are directly affected by sodium ions

Receptor potential - change in resting potential across membrane of receptor cell caused by a stimulus

Sodium ions flow in through channel proteins

Membrane is depolarised and causes receptor potential

Voltage-gated calcium ion channel proteins open

Calcium ions enter the cytoplasm and lead to exocytosis of vesicles containing neurotransmitters

Synapses

Synaptic cleft - 20nm

Cholinergic synapse - uses acetylcholine as neurotransmitter

Arrival of action potential stimulates opening of Na+ and Ca2+ voltage-gated channel proteins

Ca2+ ions move in, causing vesicles containing ACh to move into presynaptic membrane and fuse with it, releasing ACh into synaptic cleft

Receptor proteins on cell surface membrane of postsynaptic neurone are complementary to ACh and allow it to bind

Receptor proteins undergo complementary shape change and allow Na+ ions to enter the postsynaptic neurone

Postsynaptic membrane is depolarised and new impulse occurs

Acetylcholinesterase hydrolyses ACh to acetate and choline

Prevents permanent depolarisation of postsynaptic neurone

Allows ACh to be recycled - products are brought back to presynaptic neurone

ACh diffuses across the synaptic cleft

Roles of synapses

Ensures one-way transmission, as receptors are only on one side

Allows interconnection of nerve pathways - many neurones to one, or one to many