Bioenergetics and Abnormal Functional Connectivity in Psychotic Disorders
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Abstract
Psychotic Disorders such as schizophrenia (SZ) and bipolar disorder (BD) 以 neural networks such as the default mode network（DMN） 内 functional connectivity（FC）异常为特征，同时DMN和TPN（task-positive networks ）之间attenuated anticorrelation
Bioenergetic processes are critical for synaptic connectivity and are also abnormal in psychotic disorders.
research： the association between brain energy metabolism and FC in psychotic disorders
Introduction
dysconnection syndromes
DMN 同 以impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive 为特征的疾病有关
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DMN including the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and bilateral inferior parietal lobule (IPL)
The flow of metabolites through the CK reaction (abbreviated CK flux) can be quantified in vivo using a technique called 31P magnetization transfer magnetic resonance spectroscopy (31P-MT-MRS)
Since energy metabolism and related mitochondrial functions are critical for sustaining fundamental neuronal mechanisms (including maintenance of ion gradients, intracellular signaling, and synaptic neurotransmission) and BOLD signal is correlated with local field potential and synaptic activity , we hypothesized that FC would be associated with regional bioenergetic activity indicated by CK flux, and this relationship would be abnormal in psychotic disorders.
RESULTS
MATERIALS AND METHODS
Subjects
Magnetic Resonance Imaging
In Vivo 31P-MT-MRS Experiments
fMRI Data Processing
DTI Data Processing
31P-MRS Data Processing
Statistical Analyses
Demographic and clinical variables
CK flux
DISCUSSION
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