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CVS drugs, MEDICATIONS FOR HEART FAILURE TREATMENT, Medications for…
CVS drugs
Lipid lowering medications
Omega 3 acid ethyl esters
Drug: Omacor
omacor is just eicosapentaenoicacid(EPA) + docosahexaenoicacid(DHA) ethyl esters
MOA
Adverse effects
PCSK9 inhibitors
Drugs: Evolocumab, alirocumab
MOA
Adverse effects
Fibrates
Drugs: gemfibrozil ,fenofibrate
Adverse effects
MOA
Bile acid binding resins
Cholestyramine
MOA
Adverse effects
HMG-COA reductase inhibitors (“Statins”)
Drugs: pravastatin, simvastatin, atorvastatin, lovastatin, fluvastatin
MOA
Adverse effects
Inhibitors of intestinal sterol absorption
Ezetimide (zetia)
MOA
Adverse effects
Anti arrhythmic medications
Class 1A: procainamide
MOA
Adverse effects
Class 1B: lidocaine
MOA
Adverse effects
Class 1C: flecainide
MOA
Adverse effects
II (beta blocker): metoprolol
MOA
Adverse effects
III (K+ channel blocker): dovetailed, ibutilide
MOA
Adverse effects
IV (Ca+ channel blocker): verapamil
MOA
Adverse effects
Anti hypertensive medications
Tier 1: first line
Inhibitors of angiotensin
AT1 blockers
Drugs: Valsartan, losartan (case drug), candesartan, irbesartan, telmisartan
ACE-I
Drugs: Lisinopril (case drug), captopril, enalapril
Beta adrenoreceptor antagonists: beta blockers
Atenolol, bisoprolol (case drug), carvedilol, nebivolol, proponolol
Calcium channel blockers (dihydropyridines)
Amoldipine, nifedipine (case drug) (vs verapamil)
Diuretics (thiazides and thiazide-like)
Metolazone, hydrochlorothiazide, indapamide
Tier 2: second line
Hydralazine (no case drug)
Hydralazine
Mineralocorticoid receptor antagonists
Spironolactone (case drug) , explore one, finerenone
Alpha blockers (no case drug)
Prazosin, alfuzosin, terazosin
MEDICATIONS FOR HEART FAILURE TREATMENT
ACE inhibitors
Angiotensin-2 receptor blockers
Sacubitril-valsartan
beta blockers
non selective
carvedilol
cardioselective (beta 1)
bisoprolol
metoprolol XL
mixed (3rd generation)
nebivolol
diuretics
specifically loop diuretics, which are diuretics that target the Loop of Henle
hydralazine
Cardiac Glycosides
Medications for coronary (ischaemic) heart disease
vasodilators
nitrates
calcium channel blockers
cardiac depressants
beta blockers
cardiac pacemaker retardant
ivabradine
ANTITHROMBOTIC & ANTIPLATELET MEDICATIONS
Antiplatelet drugs
deactivating the platelets
Non-steroidal
anti-inflammatory drugs
aspirin
platelet GPIIB/IIIA
receptor blockers
abciximab eptifibatide and tirofiban
ADP receptor
Blockers
Ticlopidine, Clopidogrel
PDE inhibitor
Dipyridamole
Anticoagulants
prevent coagulation process via the coagulation pathway
Heparin
derivatives
Coumarin Derivatives
wafarin
Lepirudin
hirudin
antithrombin III
thrombolytics
break up the coagulation after it has happened
t-PA/alteplase
urokinase
streptokinase
anistreplase
covered in other lectures
Ivabradine
Isosorbide mononitrate / dinitrate