Please enable JavaScript.

Coggle requires JavaScript to display documents.

Genetics of obsessive-compulsive disorder (OCD) - Coggle Diagram

- - - - Familial Clustering - OCD tends to run in families, with first-degree relatives
      - Onset and Symptom Dimension Familiality: The prevalence of OCD is substantially higher in relatives of individuals with early onset OCD compared to later onset.
      - Overlap with Other Disorders: OCD shares genetic and phenomenological features with Tourette syndrome, ADHD, anxiety disorders, and autism spectrum disorders (ASDs).
    - - Heritability of OCD: Twin studies show a substantial heritability of OCD and obsessive-compulsive symptoms.
      - Twin Correlations: Monozygotic (MZ) twin correlations are consistently higher than dizygotic (DZ) twin correlations, suggesting a genetic influence on the disorder.
  - - - . Initial genome-wide studies failed to identify significant variants, though subsequent meta-analyses highlighted potential loci near genes like BTBD3 and PTPRD.
    - - Single-nucleotide polymorphism (SNP)-based heritability studies provide insights into the genetic architecture of (OCD)
      - Overall, common genetic variants contribute significantly to the variance of OCD, suggesting a substantial genetic component.
    - - mainly focusing on DNA methylation.
    - - (OCD) often occurs alongside various psychiatric disorders like anxiety disorders, Autism Spectrum Disorder (ASD), Tourette syndrome, anorexia nervosa, and Attention-Deficit/Hyperactivity Disorder (ADHD).
      - However, while OCD and ASD share some behavioral traits, they don't seem to have a significant genetic correlation. Similarly, although OCD and ADHD frequently coexist, they have limited shared genetic factors.
    - - However, two genes (GRID2 and GRP135) associated with OCD were only found to be linked to females, not males