Please enable JavaScript.

Coggle requires JavaScript to display documents.

Chemotherapy - Coggle Diagram

- - - - Binds to DNA and inhibits DNA and RNA synthesis
        stabilised DNA topoisomerase II complex, halting replication
- - - - MOA
        
        Interferes with thymidylate synthesis
      - Pharmacokinetics
        
        PO, IM, IV, Intrathecal
      - Resistance
        
        Can develop
      - Indications
        
        Auto-immune conditions
      - Adverse Effects
        
        Bone marrow suppression 🦴
        
        Mucosal changes in the GI tract (mouth ulcers) 👄
        
        Pneumonitis
        
        Nephrotoxicity high doses 🫘
- - - - Cyclophosphamide
      - Ifosfamide
      - Chlorambucil
      - Melphalan
      - Estramustine
    - - Combine with DNA and cause abnormal cross-linkages with guanine bases-adds an alkyl group
    - - WBC cancers
      - Lymphoma
      - Multiple myeloma
    - - N+V 🤢
      - Alopecia 🧑‍🦲
      - Haemorrhaguc cystitis "Mesna"
  - - - Cisplastin
        
        High nephrotoxicity and emetogeicity
        Need to follow strict regimens for hydration
      - Carboplatin
      - Oxaplatin
    - - Cross link guanine bases, inhibiting DNA repair and synthesis
      - Results in local denaturing of DNA
- - - - Antimetabolites
      - Alkaloids
    - - Alylating Agents
      - Platinum Agens
      - Nitrosureas
    - - Kinase inhibitors
      - Monoclonal antibodies
  - - - Heterogenous populations killed
      - Reduced development of resistance
      - Increased cell cytotoxicity
    - - Individual anti-neoplastic actions
      - Non-overlapping toxicities
      - Different MOAs
- - - - Max effect Day 15-17, recovery at D21
        Predisposes to infx (gram -ve)
        Haemopoietic growth factoros
  - - - DNA damaging agents → Therapy related myeloid neoplasms (t-MNs)