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Antineoplastic Drugs - Coggle Diagram

- - - - targets: epidermal growth factor receptor
      - treats: non-small cell lung cancer
    - - targets: BRAF serine/threonine kinase
      - treats: melanoma
    - - BCR-ABL (target)
      - Treats: CML (cancer)
      - taxern oraly
    - - targets: platelet derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR)
      - used for gastrointestinal stromal tumors, renal cell carcinomas, other solid tumors
  - - - Menopausal symptoms
        
        blood clots
        
        Bone loss
        
        Cataracts
        
        Endometrial cancer
  - - - Rituximab
        
        treat B-cell neoplasms including multiple myeloma & others
        
        Mechanism: Anti- CD20!! once bound to CD20 on the surface of a tumor cell, the Fc part of the monoclonal antibody can mediate tumor cell destruction by activating complement on the tumor cell surface or through antibody dependent cellular toxicity to drug resistance
      - Bevacizumab
        
        targets VEGF to inhibit angiogenesis
        
        Treats: colorectal, ovarian, renal, cervical, non-small cell lung cancer, and gliobastoma.
      - Cetuximab
        
        targets EGFR to inhibit cell proliferation
        
        treats: metastatic colorectal cancer, certain head and neck cancers
      - Immunomodulatory therapies using monoclonal antibodies to PD-1 and CTLA-4
        
        efficacy in treating metastatic melanoma.
      - administered by IV
- - - - Active form: acrolein
      - Byproduct: chloroacetaldehyde
        
        neurotoxic and nephrotoxic
- - - - muscle breakdown
      - impaired wound healing
      - immunosuppresion
      - amenorrhea
      - growth failure
      - cataract formation
      - pancreatitis
      - GERD
      - hyperglycemia
      - avascular necrosis
      - hyperlipidemia
      - mood changes
      - hypertension
      - acne
      - obesity
- - - - IV
    - - Clofarabine
      - Cladribine
      - Fludarabine
  - - - inhibits DNA polymerase
- - - - MTIC
- - - - Vinblastine
      - Vincristine
    - - Destabilization of microtubules
  - - - Docetaxel
      - Paclitaxel