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Cancer therapy: chemotherapy - Coggle Diagram
Cancer therapy: chemotherapy
Agents targeting
DNA synthesis
They do not only target
cancer cells
, but also
highly proliferating tissues
. It's not possible to clearly target only one of these 2 populations
Side effects
IS
GI tract
Liver
Gonads
Skin
Narrow therapeutic window
However, they do not act much on
cancer SCs
, which do not proliferate much
ex. Alkylating agents
PK
is important: to patients, the
maximum tolerated dose is administered
Agents acting on
mitosis
All of these options elicit a
resistance response
Higher metabolism
Higher excretion
Drug extrusion from cells
Other strategies different than classical chemotherapy
Hormonal antagonists
Differentiating agents
Using endogenous compounds which are natural inhibitors of the IS, like glucocorticoids
Side effects related to reduction in the activity of the IS
Combined
therapy can help manage/cure cancer
Novel approaches:
targeted therapy