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Pseudomonas aeruginosa - opportunistic pathogen - Coggle Diagram
Pseudomonas aeruginosa - opportunistic pathogen
morphology
Gram negative
Rod shaped
flagella and pilli
Metabolic Properties
Heterotroph - using a broad range of carbon compounds
Facultative anaerobe that grows best in oxygen but can use nitrate as a terminal electron acceptor
May ferment arginine
Grows 4-42oC so is psycho-tolerant
Differences between Pan genome and the Core genome
Core genome contains genes essential to the species survival
Pan genome is the total of all genes any strains may have that contribute to survival and growth
When will it cause infection
Immunocompromised and chronically ill patients
Individuals with cystic fibrosis (CF)
Burn patients
Which strain of antimicrobial resistant
P. Aeruginosa is a WHO priority pathogen
Carbapenamase resistant strains
characteristics that contribute to virulence of this species.
Lipopolysaccharide
Secretion of toxins and other virulence factors
Surface structures and motility
Quorum Sensing
Biofilm formation
Role of flagella and Pilli
Flagella may help with binding to mucin found in CF sputum
Pili help bacteria to bind to epithelial cells
Types of molecules secreted that might contribute to virulence
Exotoxins
Hydrogen cyanide
Proteases
What are biofilms and how do they contribute to antimicrobial resistance in P. aeruginosa?
Aggregate forms where exopolysaccharide surrounds the cells and resists stressors such as bacteriophage host immune components … and antibiotics!
Characteristics contribute to the antimicrobial resistance observed
secreted polysaccharide
Efflux pumps
Cell envelope