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Bacillus anthracis, LF is a zinc metalloproteinase which acts to suppress…
Bacillus anthracis
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Pathogenesis
Host Range - Most warm blooded soecies, mainly herbivores. Carnivores and birds are generally resistant
Transmission - Via spores primarily. In endemic areas of Africa and S.E. Asia cases are associated with livestock
Infection - Cuts or lesions to skin or mucosa could allow spore entry. Inhaled spores reach the thoracic lymph nodes. Spores display rapid germination & production of toxins in suitable environments (phagosome). Systemic infection. Local phase spore germination. Phagosome
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Prevention
Livestock management improvement, via vaccanations, controls such as quarantine
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Biohazard Group 3 - suspect a large no. of organisms - if suspected protective skin barriers and do not open suspected carcasses
LF is a zinc metalloproteinase which acts to suppress immune functions including phagocytosis. EF is an anenyly cyclase which agian supresses immune cells functions. the toxins can also work together to have sytemeic effects
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