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Clinical Studies - Coggle Diagram

- - - - HbA1c Improvement sustained -0.71% over Plcebo at 52 weeks
      - Linagliptin or placebo had little effect on renal function Median change in eGFR -0.8 Vs 2.2 Placebo/ no drug related renal failure accured
- - - - 38% Reduction in CV Death
      - 32% Reduction in all cause mortality
      - 35% Reduction in HHF
      - 14% Reduction in 3P MACE
    - - 39% Reduction in new Onset or worsening Nephropathy
      - 44% Reduction in Doubling of Serum creatinine with eGFR ≤ 45 mL/min/1.73 m2
      - 38% Reduction in new onset of Macroalbuminuria
      - 46% reduction in Hard Renal Outcomes