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CRYPTOSPORIDIUM PARVUM, Cryptosporidium_LifeCycle_lg, The-structure-of…
CRYPTOSPORIDIUM PARVUM
INTRODUCTION
•1907-Tyzer from lab mouse
•1976-1st human case.
•Oopurtunistic pathogen.
•Cause secondary infection
to immunocompromised
patients.
• Cryptosporidium Parvum-
Causative agent in human
•Habitat-Epithelial layer of intestine
MORPHOLOGY
•Oocyst.
•4-50micrometre in diametre
•Double walled cyst.
•4 cresent shaped.
•Naked or non encysted sporozoite.
•from contaminated food
And water
PATHOGENESIS
☆In immunocompetant-self diarrhoea
☆Immunodeficient and immunocompromised- ☆symptomatic intestinal and respiratory cruptosporiodiosis
☆Immunocompromised- Prolonged,Life threateningcholera like illness
Respirqtory cryptosporidiosis cholecystitis,pancreatitis,Pacreatitis
Infevtion of gall bladder
LIFE CYCLE
Human or animal host
It has two cycles
Asexual cycle
Sexual cycle
ASEXUAL CYCLE :
☆ The oocyst form attach to the tissue then taken to the intestinal layer
☆ By gastric juices the cyst wall will be broken so the sporozoite released out and attach to the epithelium layer.
☆These sporozoite will transform to the trophozoite form then it will start multiplication and start develop meront it is called as Type 1 meront.
☆ 8 merozoites released out from the Type 1 meronts.
☆ These 8 merozoites either again it will infect the epithelial layer or some times they form Type 2 meronts.The Type 2 meronts release out 4 merozoites.
Sexual cycle:
4 merozoites
•Microgamont 12-16 microgametes
•Macrogamont 1 macrogametes
•Fusion of one microgamete with one fertile macrogamete results in Zygote,i.e.Oocyst.
2 chances after fertilization:
•Thick walled Oocyst-80%-Released to environment
•Thin walled Oocyst-20%-Result in autoinfection.
LAB DIAGNOSIS
☆Wet mount
☆Concentration technique
☆Modified acid fast staining
☆Immunofluorescent antibody
☆Sputum examination
☆Histopathological examination
☆Molecular examination-PCR,ELISA
TREATMENT
Immunocompetant host
Individual receoving immuno
suppresant drugs
AIDS or CongetialbDeficiency
Antimicrobila agents
•Spiramycin
•azithromycin
•Paromycin
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