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CRYPTOSPORIDIUM PARVUM - Coggle Diagram
CRYPTOSPORIDIUM PARVUM
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•1907-Tyzer from lab mouse
•1976-1st human case.
•Oopurtunistic pathogen.
•Cause secondary infection
to immunocompromised
patients.
• Cryptosporidium Parvum-
Causative agent in human
•Habitat-Epithelial layer of intestine
MORPHOLOGY: 
•Oocyst.
•4-5micrometre in diametre
•Double walled cyst.
•4 cresent shaped.
sporozoite.
•from contaminated food
And water
LIFE CYCLE:
Single host- Human/Animal
2 cycles-
Asexual-Schizogony
sexual-Gametogony
LIFE CYCLE
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It has two cycles
Asexual cycle
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☆ By gastric juices the cyst wall will be broken so the sporozoite released out and attach to the epithelium layer.
☆These sporozoite will transform to the trophozoite form then it will start multiplication and start develop meront it is called as Type 1 meront.
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☆ These 8 merozoites either again it will infect the epithelial layer or some times they form Type 2 meronts.The Type 2 meronts release out 4 merozoites.
Sexual cycle
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•Fusion of one microgamete with one fertile macrogamete results in Zygote,i.e.Oocyst.
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PATHOGENESIS:
In immunocompetant-self diarrhoea
Immunodeficient and immunocompromised- symptomatic intestinal and respiratory cruptosporiodiosis
Immunocompromised- Prolonged,Life threateningcholera like illness
Respirqtory cryptosporidiosis cholecystitis,pancreatitis,Pacreatitis
Infevtion of gall bladder
LAB DIAGNOSIS
Wet mount
Concentration technique
Modified acid fast staining
Immunofluorescent antibody
Sputum examination
Histopathological examination
Molecular examination-PCR,ELISA
TREATEMENT:
Immunocompetant host
Individual receoving immuno suppresant drugs
AIDS or CongetialbDeficiency
Antimicrobila agents
•Spiramycin
•azithromycin
•Paromycin