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CRYPTOSPORIDIUM PARVUM, Cryptosporidium parvum is one of several species…
CRYPTOSPORIDIUM PARVUM
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LIFECYCLE
From the contaminated food🥞🥗 and water 💧 reaches the intestine and attaches to intestinal epithelial layers.
After the insertion the cyst wall will be broken down because of the acidic condition and release sporozids
• then it converted into Tropozoites
•Tropozoits will multiply and starts to develop
•it'll develop as meront [type l meront] totally 8 meront released from type l meront.
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Cryptosporidium parvum is one of several species that cause cryptosporidiosis, a parasitic disease of the mammalian intestinal tract
Found by Tyzer in 1907 from laboratory mouse it was the first infection.
• First human infection found in 1976
Optimistic pathogen in immunosuppressed, immunodeficiency individual.
Example - C.felos, c. Canis , c.muris
•Oocyst- 4-5 micro meter diameter
•Double wall cyst covering or wall
•crescent shaped sprozoits. Those are have 4
•Anterior end -pointed
•posterior end-Rounded
•These sporozoits contains nucleus
•cyst are the infective thing in human
HOST
Single host- human or animal
• Sexual and asexual reproduction
Sexual-Schizogony
Asexual-Gumetogony
INFECTIVE FORM
•sporulated oocyst
MODE OF TRANSMISSION
•contaminated food🍲🍜, water💧
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•Immunocompetant : noramal healthy individual
•Immunocompremised person- short term, life limiting diarrhea lasting approximately weeks
Cholera infection like infection, prolonged, life threatening.
•respiratory cryptospondiosis, hepatitis pancrratitis, gall blader infections
•Stool sample
•Direct wet mount
• stool concentration techniques
•modified acid fast staining
•Immuno fluorescent antibody
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AIDS- continues supportive therapy
Individual recovery- immunosuppressive drugs
Antimicrobial agents for cryptosporidiasis
•Spiramycin
•Paromycon
•Octreotide
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