CRYPTOSPORIDIUM PARVUM 
1 st REPORTED BY TYZER IN 1907 HUMAN INFECTION (1976) IDENTIFIED FROM LABORATORY MOUSE
HABITAT
EPITHELIAL LAYER
MORPHOLOGY
TWO LAYER - ELECTRON DENSE REGION.
CONTAMINATED FOOD OR WATER THE CYST FORM OF CRYPTOPORIDIUM
HAS 4 CRESCENT SHAPED NAKED OR NON- ENCYSTED SPOROZOITES.
SPOROZOITES- ANTERIOR : POINTED, POSTERIOR : ROUNDER HAS NUCLEUS
ONE FORM - CYST ( OOCYST)
4 -5 DIAMETER
LIFE CYCLE
ASEXUAL CYCLE : SCHIZOGANY
SEXUAL CYCLE : GAMETOGONY
SINGLE HOST : HUMAN OR ANIMALS (CATTLE , CAT, DOG)
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ASEXUAL CYCLE
BY INTESTINAL GASTEIC JUICES BREAKS THE CYST WALL
SPOROZOITES WILL BE RELEASED OUT
ATTACH THE TISSUES AND SLOWLY TAKEN TO THE INTESTINAL LAYER
EXCYSTATION OCCURS SPOROZOITES ATTACH TO INTESTINAL LAYER AND CONVERT INTO TROPHOZOITES
INGESTION OF CONTAMINATED FOOD AND WATER
IT STARTS MULTIPLICATION
INSIDE TROPHOZOITE FORMS, DEVELOP; MERONT INSIE WHICH IN TYPE 1 - MERONTS
THERE WILLL BE RELEASE OF 3 MEROZOITES
IT WILL BE AGAIN INFECTS THE INTESTINAL EPITHELIAL LAYERS OR FORM TYPE 2 MERONTS IT RELEASE 4 MEROZOITE
MEROZOITES PRODUCTION IS ASEXUAL CYCLE
SEXUAL CYCLE
RESULTS IN ZYGOTE FORMATION ( OOCYST FORM )
1 MICROGAMETE IS S;UFFICIENT TO FERITILIZE THE MACROGAMETE
EITHER FORMS THICK (DOUBLE WALL ) OOCYST OR THIN ( SINGLE WALL ) OOCYST
80% WILL BE THICK WALL FORMATION
FROM 1 MACROGAMONT, IT RELEASE 1 MACROGAMONT
20% WILL BE THIN WALL FORMATION
FROM 1 MICROGAMONT, IT RELASES OUT 12 TO 16 MICROGAMONT
THICK WALLED RELEASED WITH FEACES
FROM 4 MEROZOITES FORMS MICROGAMONT AND MACROGAMONT
THIN WALLED COVERINGS CAUSE AUTO- INFETION
LAB DIAGNOSIS
MODIFIED ACID FAST STAINING- OOCYST APPEAR BRIGHT RED AND YEAST TAKE UP BLUE COLOUR
SPUTUM EXAMINATION HAEMOTOXYLIN AND EOSIN STAINING
STOOL EXAMINATION
DIRECT WET COUNT - HIGHLY REFRACTIVE, OVAL OOCYST MEASURING 4 TO 5 IN DIAMETER STOOL EXAMINATION TECHNIQUE - IDENTIFICATION OF OOCYSTS
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INFECTIVE FORM - SPORULATED OOCYST
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PATHOGENICITY
INFECTION OF GALL BLADDER, CYST PASSED IN STOOL
IMMUNOCOMPETENT - SELF LIMITING DIARRHOEA 1 WEEKS
IMMUNOCOMPETANT AND IMMUNODEFICIENT INDIVIDUALS SYMPTOMATIC INTESTINAL AND RESPIRATORY CRYPTOSPORIDIUM
TREATMENT
ANTIMIROBIAL AGENT FOR CRYPTOSPORIDIASIS- PAROMYCIN, SPIRAMYCIN