membrane phospholipids (arachidonic acid)

phospholipase 2

arachidonic acid

lipoxygenase

leukotrienes

Lc4, d4, e4

COX 1 and 2

cyclic enteropeptidase

e

cyclin

H2

B4

D

neutrophil chemotaxis

glucocorticoid block

cox 1 and 2 block= NSAID

cox 2 block celecoxib

I

vasodilation

increase bronchial tone

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also positiVE IKB

-nfkb

  • NFKB to activate cox 2