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Smooth Muscle, oxytocin, GS, PGE, NO/CGMP, calmodulin activates, GI -…
Smooth Muscle
Contraction
myosin light chain kinases phosphorlate
myosin light chain kinase
CAMP inhibits
PKA
relaxation/decreased tone
Myosin light chain phosphatase
myosin light chain dephosphorlate
oxytocin
GQ coupled receptor
Phospholipase C
IP3
increase CA from SR
CA binds calmodulin
uterine contraction/ milk letdown
GS
PGE
adenylate cyclase increase camp
adrengic nerve terminals
NO/CGMP
calmodulin activates
GI