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Neuropharmacology - Coggle Diagram
Neuropharmacology
Blood Brain Barrier
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This limits the ability of substances other than H2O, CO2 & O2 to enter the brain parenchyma
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Inhibition Type 1 Drugs
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- COMT inhibitor (increase dopamine release)
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Nerve Synapse
Presynaptic nerve: NT synthesis, storage, release
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Degeneration of Neurons
- Cell death = less dopamine release in the neostriatum
- Loss of inhibitory effect of dopamine = more production of Ach, triggers chain of abnormal signalling leading to impaired mobility
Stimulation Type 2 Drugs
Anticholinergic Drugs: benzotropine, diphenhydramine, procyclidine, trihexphenidly
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Receptor Empty A: membrane potential in neurons- inside - charge (proteins); outside- + charge (Na+,K+,Cl-)
Receptor binding of excitatory NT B: Depolarisation (& repolarisation) of the membrane during action potential
Excitatory NT: binding of the agonist to the ionotropic receptor decreases the - charge = helps to activate the cell
Inhibitory NT: binding pf the agonist to the ionotropic receptor increases the - charge = supports the silencing of the neuron
Neurotransmitters selected:
Acetylcholine- several pathways in the brain, excitatory
Noradrenaline & adrenaline- high limbic system
Dopamine- involved in the coordination of impulses & responses
Gamma-aminobutyric acid (GABA)- inhibits nerve activity & important in preventing overexcitability or stimulation such as seizure activity.
Serotonin- important in arousal & sleep & in preventing depression & promoting motivation.
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Tyramine increases NA release @ synaptic terminal, normally metabolised by MAO in periphery. MAOi increases tyramine levels= Hypertensive crisis