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DNA DAMAGE AND REPAIR - Coggle Diagram

- - - - change base pair properties of a base (mutagenic)
    - - if cell attempt to replicate without damage repair
- - - - CPD photolyase
  - - - act on subtle base damage
      - begins w DNA glycosylase
        
        extrude a base, clip out the damaged base, leaves an apurinic site (attract DNA repair enzyme)
      - DNA repair enzyme
        
        remove remaining deoxyribose phosphate, replace w nucleotide, ligase seal nick
    - - repair bulky damage distort DNA double helix
      - damaged DNA clipped by endonuclease, sites 12-13 nucleotides apart
        
        uvrABC endonuclease
        
        DNA polymerase and ligase in action
      - recognize parental strand by methylated A
    - - methylated adenines determine parental strands
        
        mutH, L and S introduce nick
        
        exonuclease removed strand
        
        DNA pol and ligase
        
        Methyl transferase add CH3