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Neoplasia Development - Coggle Diagram
Neoplasia Development
Categories of
Neoplasms
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Sarcoma
Malignant neoplasm derived from mesenchymal cells (e.g., fat, muscle).
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Invasion and Metastases
The reliable features distinguishing benign from malignant neoplasms are invasion, which involves the infiltration of tumor cells into surrounding organs, and metastases, which is the spread of tumor cells to distant organs through blood (characteristic of sarcomas) or through the lymphatics (characteristic of carcinomas).
While some malignancies may not metastasize, they still exhibit invasion.
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Carcinogenesis
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- Acquire self-sufficiency in growth signals and ignore growth-inhibitory signals.
- Acquire defects in DNA repair.
- Acquire the ability to divide an unlimited number of times.
- Invade surrounding tissue, passing through the basement membrane and spreading to distant organs (i.e. metastasize).
Definition
New growth, or neoplasia, can be benign (localized) or malignant (invasive with metastatic potential).
Neoplastic cells develop mutations, disregarding normal boundaries and showing uncontrolled growth.
Malignant neoplasms gain the ability to invade surrounding tissue, breach the basement membrane, enter the bloodstream, and establish growth in distant organs.
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