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Nicotine Vaccine, A novel and efficient nicotine vaccine using nano…
Nicotine Vaccine
Nicotine Addiction :red_flag:
6 million killed in 2011
Unable to quit smoking
Dopamine neurons
induce rewarding behavior
stimulate the brain
Problem :warning:
Finding a 'delivery' vehicle
nano-lipoplex
Deliver small molecules
liposomes
made of
chloride salt
polyethylene glycol
ammonium salt
Producing effective antibodies
Experiment :silhouettes:
Tested in mice :pencil2:
Immunized days 0, 14, 28
conjugated to carrier proteins
Results
achieved higher NicAb tier
reduce nicotine entering brain
Future Work :checkered_flag:
Impacts the Industry
Validity for human testing
Increase in effectiveness
Develop a usable vaccine
Broader Picture :silhouettes:
Impacts commercialization of cigarrettes
Fail or lose business
Economic damage reduction
$1b economic damages incurred 2011
Leads to regulations
Government
Incentivized to fully eliminate depenance
Eliminating dependance
Companies lose demand
Lose profit
Saving lives
Reduction in deaths :!!:
Better health
Healthcare system sees alleviation
Human vaccine
Combat tobacco/nicotine dependance
Molecular Understanding :<3:
Nictone binds to receptors
Dopamine receptors recieve nicotine
'reward' hormone :star:
becomes addictive
Nicotine particles are small
Difficult to 'filter'
How to stop it entering brain? :no_entry:
Delivery Systems
liposomes
vesicles large enough to encase
Effective way to deliver vaccine
A novel and efficient nicotine vaccine using nano-lipoplex as a delivery vehicle