Epithelium

Definition

Classification according to function

Distribution

Formation

Is present in almost all organs of the human
body as lining and glandular tissue.

Surface Epithelium

Glandular Epithelium

Covers all inner and outer surfaces of the body (skin and mucous membranes).

Exception

Synovial Membrane (synovium)

Composed of synoviocytes (not epithelial cells) which line the inner surfaces of joint capsules, synovial bursa, and tendon
sheaths.

Different types of epithelia are formed
from the three germ layers.

Ectoderm

Mesoderm

Endoderm

Epithelium of skin and skin appendages.

Epithelium of the respiratory and
gastrointestinal tract.

Epithelium of serous membranes (mesothelium): Peritoneum,
pleural, and pericardial cavities

Cells lining the inner surface of blood and lymphatic vessels
(endothelium).

Defintion

Function

Classification

Specialized layer of tissue formed by closely aggregated cells that line the outer surface of organs, blood vessels, the skin, and the inner surface of body cavities.

Divided into

Columnar

Cuboidal

Squamous

Protects against mechanical/chemical effects and harmful
radiation.

Resorption: e.g., nutrients in the gastrointestinal tract.

Surface epithelia are classified
according to the number of layers and cell shape.

Criteria for Classification

Layers

Simple Epithelium

Pseudostratified Epithelium

Stratified Epithelium

Cell Shape

Cell shape of the upper cell layer of a type
of epithelium determines the name for the whole epithelium.

Flat (Squamous Epithelium)

Appearance: Upper cells have a squamous (flat) shape (width >
height).

Examples: skin , esophagus , cervix , serous
membrane (e.g., peritoneu).

Cube-shaped (Cuboidal Epithelium)

Have a slightly irregular shape, and a small, centrally located nucleus. These cells can be stratified into layers, as in (Right) this human cervix specimen.

Appearance: Upper cells have a cube-like shape (width = height).

Examples: bile ducts , renal tubules

Column-shaped (Columnar Epithelium)

Appearance: Upper cells have a rectangular or cylindrical shape (width < height).

Examples: intestine , respiratory tract (respiratory epithelium).

Epithelial Specialization

Keratinization (horny layer)

Differentiated into the horny layer (keratinization) and cell
projections (microvilli, stereocilia, kinocilia).

Only found on the skin (stratum
corneum). The epidermis is a keratinized stratified
squamous epithelium

Cell Projections

Microvilli

Stereocilia (Stereovilli)

Cilia

Microvilli are tiny finger-like projections on cells, especially in the small intestine, aiding in nutrient absorption by increasing surface area.

They form structures like the brush border, found on both absorptive and secretory surfaces, and vary in length and composition. In the immune system, they are common on lymphocytes.

Stereocilia are non-motile cell modifications, similar to microvilli but longer and thicker.

They contain actin, lack an axoneme, and are found in the vas deferens, epididymis, and inner ear sensory cells.

Unlike cilia, stereocilia lack a basal body, may or may not have a glycocalyx coating, and have no fixed arrangement.

Cilia are small hair-like structures on mammalian cell surfaces, involved in both locomotion and mechanoreception.

They can be single or multiple, and organisms with cilia are called ciliates, using them for feeding and movement.

Types of Cilia

Motile Cilia

Non-motile Cilia

Numerous cilia on cell surfaces, particularly in the respiratory epithelium of the human respiratory tract, clear mucus and dust from the lungs.

Discovered in 1898, primary cilia were initially thought to be vestigial but now serve as non-motile sensory antennas coordinating cellular signaling pathways.

They play key roles in kidney cell signaling for urine flow, act as mechanoreceptors, and facilitate particle transfer in the retina.

Glandular epithelium, whether single cells or groups, produces and secretes specific products like mucin.

It typically invaginates into connective tissue but is separated by the basal lamina.

Glandular epithelium can be either endocrine (secreting into the bloodstream) or exocrine (secreting onto a surface).

Classification

The type of secretion associated with it

Secretory Mechanism

Location & Shape

Intraepithelial Glands

Glandular cells that are located within the surface
epithelium.

Shape

Goblet Cells

They have a characteristic vacuole filled with mucus and function to secrete mucins.

Goblet cells are single intraepithelial glandular cells found in the small and large intestines, nasal mucosa, and respiratory tract.

Secretory Epithelium

Columnar epithelial cell conglomerates with bright cytoplasm (mucus-filled), lacking a vacuole.

Found in locations like the surface epithelium of the stomach and cervical canal, where they form entirely secretory epithelium.

Extraepithelial Glands

Extraepithelial glands migrate during embryogenesis from surface epithelium into underlying connective tissue, resulting in an elaborate structure.

Terminal Ends

Excretory Ducts

Closed gland connected to excretory ducts for secretion production, with various terminal ends.

Functions include the production and release of secretions into the lumen, draining into the excretory duct system.

Shapes of the terminal ends of exocrine glands

Acinar Glands

Alveolar Glands

Form: berry-like , narrow lumen
Examples: parotid gland, pancreas

Shape: sac-like , wide lumen
Examples: apocrine sweat glands

Tubular Glands

Shape: tubular; wide, elongated lumen Examples: gastric glands (foveolas in the stomach),
colonic crypts

Subtypes

Simple branched tubular (e.g., meibomian glands)

Coiled tubular (e.g., eccrine sweat glands)

Mixed Forms

Tubuloacinar, tubuloalveolar

Epithelial-lined ducts connect glandular cells to the gland opening, facilitating secretion drainage and modifying its nature.

Duct shapes vary due to subdivision into lobules by connective tissue septa in extraepithelial glands.

Intralobular Ducts

Interlobular Ducts

Excretory Ducts

Within lobuli, drain secretions to larger interlobular ducts

In broad connective tissue septa, lead to excretory ducts, the thickest segment

Collect secretions from terminal ends and divert them to the gland opening.

Examples include bilayered columnar epithelium in terminal excretory ducts of various glands, such as apocrine and eccrine sweat glands and esophageal glands.

Exocrine glands are intraepithelial glands or extraepithelial
glands that release their secretions on the inner (e.g.,
intestinal lumen) or outer (e.g., skin) surfaces of the body.

Eccrine Secretion

Release of ions and small molecules facilitated by transmembrane proteins through membrane protein transport. Found in almost all exocrine gland cells.


Merocrine Secretion

Secretion release rich in proteins occurs through cytosolic vesicle fusion with the cell membrane, utilizing the mechanism of exocytosis. Commonly found in exocrine glandular cells, such as salivary and sweat glands.

Apocrine Secretion

Lipid-rich secretions are released as a portion of the apical cytoplasm buds off, involving the cell membrane. This process, known as apocrine secretion, occurs exclusively in apocrine sweat glands and lactating mammary glands.






Holocrine Secretion

Entire cytoplasmic content is released through gland cell destruction via apoptosis. This mechanism, called holocrine secretion, is exclusive to sebaceous glands.

Serous Glands

Mucous Glands

Seromucous Glands

Low viscosity, protein, and enzyme-rich secretion, characterized by acinar glands, basal-rich rough endoplasmic reticulum, and apical granular secretions. Examples include the parotid gland and pancreas.

Viscous, mucin-rich secretion characterized by tubular glands with pale, bright cytoplasm. Examples include sublingual gland, esophageal glands, Brunner's glands, and all intraepithelial glands.

Low viscosity secretion containing both mucin and enzymes. Terminal end is mainly tubuloacinar with a serous demilune. Gland cells exhibit characteristics of both serous and mucous cells. Example: Submandibular gland.

A single layer of epithelial cells with all cells attached to the basement membrane.

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A single layer of cells with the appearance of multiple layers as a result of the nuclei positioned at different levels.

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Two or more cell layers with the basal layer attached to the basement membrane.

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