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Cell, Glycolipids - Coggle Diagram

- - - - Three major types
        
        Phospholipids
        
        Most common, one saturated and one unsaturated tail, glycerol or spingosine backbone, negtively charged or neutral, found on both leaflets
        
        Can be used for Signaling
        
        PI and PtdIns
        
        General fxns
        
        Less than 1% of PM
        Cytosolic leaflet
        
        Clathrin mediated the internalization process, recognizes PI(4,5)P2
        
        Ligand binds to
        extracellular surface
        
        PLC activation
        
        1 more item...
        
        Sterols
        
        Abundant, one tail, bulky bb, small polar head group, found on both leaflets
        
        Glycolipids/Cholesterol
      - Functions
        
        Non-Structural Aspect
        
        Regulates membrane
        Protein activity
        
        Dependant on Calcium ion
        concentration being low in cytosol
        
        Lipid Rafts
        
        Transmembrane proteins
        preferentially enriched
        
        Glycolipids can be
        recognized by lectins
        
        Biosynthetic precursors to
        signaling molecules
    - - Two main types of proteins
        
        Beta Strands
        
        Stability comes from the hydreogen bond from
        c=o and the N-H of a neighboring strand
        
        Alpha Helix
        
        Stability comes from the hydreogen bond from
        c=o and the N-H of the same chain
        
        Sugar modifications are common forming glycoproteins in the extracellular/lumenal side
      - Lipid anchored proteins
        
        First Synthesized
        in the ER
        
        A GPI anchor is attached to C-terminus
        
        Lipid anchor resids on lumenal/extracellular leaflet
      - Integral membrane proteins
      - Peripheral Membrane proteins
        
        Can be extracellular or lumenal
        associated with other proteins via
        hydrophilic intx