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Principles of Pathogenesis, Localized infection - Coggle Diagram
Principles of Pathogenesis
Terminology
Colonization
Microbe establishing itself on/in body
Infection
Refers to colonization by pathogen
Initial is primary infection
Predisposed individuals can under secondary infection
Primary pathogen
Can cause disease in healthy individual
Opportunistic Pathogen
Can cause disease in immunocompromised individuals
Infectious dose
Number of microbes necessary to cause infection
Incubation period
Time between exposure and onset of symptoms
Acute infection
Develop quick, short
Chronic infection
Develop slow, last long
Latent infection
Never completely eliminated
Systemic infection
Disseminates throughout body
Establishing infection in host
Virions outside of host genome
Acquiring new genes
Competence/ transformation
Conjugation
Phage transduction
Lysogeny
Adherence
First line of defence
Colonization
Growth in biofilms
Delivering toxins
Type 3 secretion system
Penetrating mucous
Direct uptake
Exploding M cells
Avoiding host immune sysem
Hiding within host cell
Avoiding abs
Avoiding complement
Avoiding phagocytes
Preventing encounters
Avoiding recognition
Surviving within phagocyte
Causing disease
Direct or indirect effects
Toxins, immune response
Damage to host cell may allow for their pathogens to exit and spread and allow the microbe to extract mutrients
Bacterial toxins
Produced by microbes, bind to surface or enter cell to perturb cellular function
Exotoxins
Damaging effects
Grouped based on tissue they effect
Neurotoxin
Cytotoxin
Enterotoxin
Categories for general structure and mechanism
A-B toxins
Membrane damaging toxins
Super antigens
Other
Endotoxins
Part of the cell, not secreted outside
LPS - lipid A (portion that is toxic)
Localized infection
Limited to.a small area