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"My Sugary Blood" - Coggle Diagram

- - - - Insulin
        
        Target: liver, muscle, adipose
        
        Stimulus: glucose
        
        Bidirectional
        
        Function
        
        Lowers plasma glucose
        Increase cellular glucose metabolism
        
        causes
        
        Glycogen synthesis
        
        Protein synthesis
        
        Triglyceride synthesis
      - Glucagon
        
        A protein hormone ( 29 amino-acids)
        
        Stimulant: low plasma glucose & amino-acids
        
        Target: G-protein
        
        Function
        
        Glycogenolysis
        
        Gluconeogenesis
- - - - Gram-positive bacteria (MRSA, MSSA)
      - Gram-negative (E. coli, Klebsiella, Proteus)
      - Anaerobic pathogens (Bacteroides, Clostridium)
- - - - given before meals
        
        Lispro
        
        Aspart
        
        Glulisne
    - - Only one given as IV
        
        Used for DKA
    - - NPH
    - - Glargine
      - Detemir
    - - Hypoglycemia
      - Weight gain
      - Hypokalemia
      - Lipodystrophy
  - - - Doctor is viewed as a friend
    - - Doctor is viewed as an advisor
    - - Doctor is viewed as father-figure
    - - Doctor is viewed as an expert
- - - - repression - reomving memories/impulses/thoughts from awareness - NOT subject to voluntary recall - can't do anything about it, but they remain with you - manifest in other ways
      - denial - protecting self from unpleasant reality by refusing to perceive it
      - displacement - emotions transferred from original object, direct to more acceptable substitute
      - reaction formation - directing overt behavior/attitude in the opposite direction of one's underlying, unacceptable impulses
      - projection - attributing to others one's own unacceptable impulses, thoughts, desires
      - rationalization - thinking up logical, socially approved reasons for behavior
      - intellectualization - use of scientific/abstract thinking as a means of avoiding affectively painful realities/thoughts
      - isolation - separating emotional components from a thought, resulting in repression of either emotion or idea
      - splitting - perceiving one's self and others as all or all bad, rather than experiencing self or others ambivalently (both good and bad present)
- - - - Insulin resistance
        
        Increased by
        
        obesity
        
        Genetic factores
      - Beta cell dysfunction
  - - - Fatigue, blurred vision and dizziness
      - Acanthosis nigricans
      - Polyuria, polydipsia & polyphagia.
  - - - Diabetic Nephropathy
      - Diabetic Neuropathy
      - Atherosclerosis
      - Diabetic Retinopathy
- - - - positive selection
      - negative selection
    - - anergy
      - induced TReg
    - - HLA-DR3 or 4
        
        precipitating factor
        
        overt immunologic abnormalities
        
        progressive loss of insulin
        
        Overt diabetes, low c-peptide
        
        no c-peptide
    - - personalized Treg cells
- - - - sulfonyureas
      - miglitinides
    - - DPP IV inhibitors
      - GLP-1 analoges
    - - metaformin
      - TZDs
    - - SGLT2 inhibitors
      - alpha-golucisudase inhibitors