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CHAPTER 8 T-Cell Development - Coggle Diagram
CHAPTER 8 T-Cell Development
Early Thymocyte Development
Thymocytes Progress through Four Double
Negative Stages
Thymocytes Express Either αβ or γδ T Cell
Receptors
DN Thymocytes Undergo β-Selection, Which
Results in Proliferation and Differentiation
Positive and Negative Selection
Thymocytes “Learn” MHC Restriction in the
Thymus
T Cells Undergo Positive and Negative Selection
Positive Selection Ensures MHC Restriction
Negative Selection (Central Tolerance) Ensures
Self-Tolerance
How Do We Delete Thymocytes Reactive to Tissue-Specific
Antigens?
Other Mechanisms of Central Tolerance
Superantigens
The Selection Paradox: Why Don’t We Delete All
Cells We Positively Select?
An Alternative Model Can Explain the Thymic
Selection Paradox
Do Positive and Negative Selection Occur at the
Same Stage of Development, or in Sequence?
Lineage Commitment
Several Models Have Been Proposed to Explain
Lineage Commitment
Transcription Factors Th-POK and Runx3 Regulate
Lineage Commitment
Double-Positive Thymocytes May Commit to Other
Types of Lymphocytes
Exit from the Thymus and Final Maturation
Other Mechanisms That Maintain Self-Tolerance
T Cells Negatively Regulate Immune Responses
Peripheral Mechanisms of Tolerance Also Protect
against Autoreactive Thymocytes