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module 1: Principles of Lab Med - Coggle Diagram
module 1: Principles of Lab Med
Chapter 1: Clinical Chemistry and Molecular Diagnostics
Ethical issues in chem
confidentiality of patient and genetic info
allocation of resources
code of conduct
publishing issues
conflict of interest
Uses of testing in clinical laboratory
confirming or excluding a diagnosis
assisting in selection, optimization and monitoring of treatment
screening for diseases in absence of symptoms
monitoring the severity
History
<1901 Robert James Graves and Max Josef von Pettenkofer scoffed at chem lab services
Mid 19-th cent when clinical lab was born
Charles Henry Ralfe coined "Clinical Chemistry"
First lab was attached to a hospital in 1886 in Munich Germany by Hugo Wilhelm von Ziemssen
the first US clinical lab was The William Pepper Lab of Clinical Medicine in 1895 at the university of pennsylvania
Molecular diagnosis first mentioned in New England Journal of medicine in 1968
1986 Molecular diagnostics defined as (pg2)
1987 it was used to describe mapping molecular diagnostics was used to describe mapping of antigenic substances by affinity chromatography using immobilized antibodies
1988 southern blotting was used for gene amplification and rearrangement
1997 PCR was found