Many advances in science have been made in the last decade to better explain the pathogenesis of PTSD. Advances in the brain imaging method have allowed us to study changes in patients' brains in a non-invasive way. Recent studies have observed the activity or morphology changes of several brain regions in patients with PTSD, including the prefrontal lobe, amygdala, hippocampus. However, it is still unclear how these changes in brain regions are linked to PTSD. Further research needs to be conducted to understand the function of brain regions during the development of PTSD. Also, people can develop PTSD, depression, or both as a result of a major traumatic event. The hypothalamic–pituitary–adrenal axis (HPA axis) may play an important role in such a difference. Glucocorticoid level has been used as an indicator for HPA axis activation and monitoring glucocorticoid level can help us understand the role of the HPA axis in the pathogenesis of PTSD. The treatment of PTSD includes pharmacotherapy, physical therapy, psychotherapy and other interventions. For example, rTMS models may provide a new approach for the prognosis and rehabilitation of PTSD patients. At present time, the means to prevent PTSD are lacking but are of great importance. The research in the pathogenesis of PTSD will eventually return to prediction, prevention and more effective treatment.