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strand 8 gene probes - Coggle Diagram
strand 8 gene probes
method
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the DNA contains the mutant allele, a probe will bind to it because of the complementary base sequence
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the hybridised DNA will now be fluorescently/radioactively labelled with the dye attached to the probe
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the dye is detected by shining light (or using a radiograph) onto the fragments causing the dye to fluoresce can be seen using a special microscope
a fragment of DNA is produced that has a sequence of bases that are complementary to the mutant allele being searched for
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personalised medicine
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example 1: some painkillers need a specific enzyme, if a patient has reduced levels of that enzyme until the dosage is adjusted the painkiller will have less effect
example 2: diabetics, vitamin E reduces risk of CVD for some genotypes but increases risk for others, vitamin E supplements could be given to those it reduces the risk for
genetic counselling
a form of social work where patients or relatives at risk of an inherited disorder are advised of the consequences and nature of the disorder, probability of transmitting or developing it and options open to them in management and family planning. used often for potential parents.