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URONIC ACID PATHWAY, Substrate, Reaction, Enzyme, Product, activated form,…

- - - - Humans lack L-gulonolactone oxidase
- - - - L-gulonolactone oxidase
        
        L-Ascorbic acid
  - - - B-L-hydroxy acid dehydrogenase
        
        3-Keto-L-gulonic acid, NADH
  - - - Glucuronic acid
  - - - B-Keto-L-gulonate decarboxylase
        
        C1 of 3 Keto-L-gulonic acid released as CO2
  - - - UDP Glucose dehydrogenase
        
        UDP Glucuronic acid
  - - - Xylitol dehydrogenase / Xylulose reductase
        
        Xylitol, NADP
  - - - UDP Glucose Phosphorylase
        
        UDP Glucose
  - - - Xylulose kinase, ATP
        
        D-xylulose-5-P, ADP
  - - - Phosphoglucomutase
        
        G-1-P
  - - - D-xylulose dehydrogenase
        
        D-xylulose, NADH, NAD
- - - - To excrete bilirubin in gut/kidney
      - Major pathway of excretion: feces
- - - - Increased L-xylulose (pentose) in urine
  - - - Vit. C for collagen synthesis
      - Weakness, anemia, limb pain, hemorrhages, dec. wound healing