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Female Physiology - Coggle Diagram

- - - - Increased frequency of GnRH favours LH production (increased during follicular phase)
      - Slower frequency of GnRH Favours FSH production (increased during preovulatory stage)
    - - Administration in non-pulsatile function abolishes FSH, LH
        
        Used in IVF clinics to shut down woman's cycle to promote oocyte collection from mature follicles
        
        Used in treatment of endometriosis, hormone dependent cancer
    - - Lupron
        
        When taken regularly, there is a flare of GnRH secretion for a few days
  - - - Progesterone
        
        Aldosterone (mineralcorticoids)
        
        17alpha-OH-progesterone
        
        Cortisol
        
        Androstenedione
        
        Testosterone (aromatase)
        
        Estradiol-17beta (sex steroids)
  - - - Suckling triggers oxytocin
        
        PRF releaseing Factor
        
        Inhibits pulsatile release of GnRH
        
        Regular suckling can maintain lactational amenorrhea
    - - Can interpere with nromal reproductive function
      - Interferes with GnRH function and affects LH
  - - - Elevated TRH increases prolactin
      - Can lead to low levels of sex homrone resulting in higher free testosterone -> PCOS
      - Menorrhagia can occur due to lack of clotting facotrs/elevated estrogen
      - Can present with irregular cycles and irregular length/amount of bleeding
    - - Precocious puberty,
      - Increased production of SHBG and increased rate of T->E conversion
      - Baseline FSH and LH are often elevated
      - Variable effects on menstrual length, flow and effect on fertility
- - - - Estradiol> Progesterone
  - - - Estradiol>progesterone
      - Specific Actions
        
        Stimulates completion of first meiotic divison
        
        Progesterone Production by granulosa
        
        Stimulates increase in antral fluid volume
        
        Stimulates release of hydrolytic enzymes to permit follicle rupture
    - - Ensure full complement of LH receptors
      - Stimulates synthesis of plasminopgen activation and of gel-like hylauronic acid
  - - - Progesterone >Estradiol
  - - - Both drop E2 begins to rise
  - - - Increase in oocyte size
        
        acquisitionn of zona pellucida, granulosa cells
        
        differential of formation of theca cells
    - - Granulosa cell comparment: Avascular, FSH-responsive, closest to oocyte
      - Theca cell compartment: vascularized, LH-responsive, outside bm follicle continues to icnrease in size as cell proliferation continues
      - FSH Stimulates
        
        Granulosa cell proliferation, granulosa estrogen production, granulosa FSH receptor production, granulosa inhibin production
        
        LH stimulates
        
        Theca cell testosterone
    - - Antrum Forms
        
        Continued growth of granulosa/theca cell compatments
        
        AS estrogen levels increase, FSH levels decline
  - - - Increased stimulatory outputs, decreased inhibitory inputs, Growth factor stimulated rodiuction
    - - Responsible for growth and maturation of breasats, fat redistributino and bone maturation
  - - - Genital tissue, urinary tract, breast atrophy, CV system, Skeleton
- - - - Posterior Lobe
        
        ADH and oxytocin storage
        
        Downgrowth of hypothalamic tissue
      - Anterior lobe
        
        Formed from epithelial tissue (outpocketing of oral mucosa - Rathke's pouch)
        
        Vascular connection: hypophyseal portal system
        
        Follicle stimulating hormone, Luteinizing homrone (LH), prolactin
  - - - FSH, LH (Anterior Pituitary)
        
        Ovaries, Testes (Target Glands)
    - - Prolactin (Anterior pituitary)
        
        Breast (Target Gland)