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Thyroid Investigations - Coggle Diagram

- - - - Only small fraction of T4/T3 is unbound and circulating
      - Thyroxine Binding Globulin
        
        High: Etrogen, pregnancy, hepatitis, opioids, idipopathic
        
        Low: Androgens, acromegaly, glucocorticoids, nephrotic syndrome, cirrhosis
      - TRAb
        
        Thyroid stimulating immunoglobulins specific for graves disease
    - - Useful for thyroid Function
      - Inject/ingest radioisotope , gamma camera, uptake
      - High RAIU: Graves disease, toxic noedules, recovery phase of thyroidits, iodine deficiency
      - Low RAIU: Subacute thyroiditis, thyroid ablation, hypopituitarism, excess iodine
  - - - Determine anatomy, and dectect nodules and/or cysts
- - - - Eye disease
        
        Occular changes: periorbital swelling, lid retraction and lid lag
        
        Infiltrative ophtamopathy: Proptosis, exophthalmos, increased edema of lids and conjuctivea, chemosis, ophtalmoplegia
    - - Antithyroid drugs, methimazole, radioactive iodine baalation, thyroidectomy
  - - - Radioactive iodine ablation
      - Thyroidectomy
      - Lifelong anti-thyroid meds
- - - - Autoimmune due to anti-TPO antibodies