"Breast cancer genes such as MAP3K1, LZTR1, ATR, and BARD1 have been identified by researchers from Canada and Europe, shedding information on increased breast cancer risk. This discovery, along with another 21 genes that may be connected to breast cancer risk, is the outcome of a large genetic data analysis comprising 26,000 women with breast cancer and 217,000 women without. These discoveries are critical for identifying people at high risk for breast cancer, the largest leading cause of cancer-related fatalities in women worldwide, and could open the path for innovative therapies. PALB2, the third most common breast cancer gene after BRCA1 and BRCA2, is involved in DNA damage repair. The risk of breast cancer is significantly increased by mutations in PALB2. Understanding the genetic basis of breast cancer is critical for early detection and customized treatment options for those at high risk." (Prater, 2023)
