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Cervical tumours, HPV - Coggle Diagram
Cervical tumours
Squamous lesions
Regular nuclei
Features
Minimal nuclear contour irregularities
Residual mucinous epithelium
Uniform chromatin
Squamous metaplasia
p16 negative
Residual mucinous epithelium
Irregular nuclei
Features
Hyperchromatic
Irregular nuclear contours
Koilocytes
Perinuclear halos
Rasinoid nuclei
Extent
1/3 up
LSIL/CIN1
Condyloma
Papillary fronds
More than 1/3 up
HSIL CIN2/3
Glandular lesions
Non-epithelial/mesenchymal lesions
HPV
Low risk
6 + 11
Nuclear integration absent
High risk
16 + 18
Nuclear integration
Oncoproteins
p53 inactivation
E6
Rb inactivation
E7