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Odontogenesis - Coggle Diagram

- - - - Bud Stage: Begins at the 8th week of intrauterine life. Enamel organs emerge, and dental buds develop.
      - Cap Stage: Occurs at 12 weeks of intrauterine life. The enamel organ expands, forming a cap over the tooth bud. Dental papilla begins to differentiate into dentin and pulp.
      - Early Bell Stage: The dental lamina disintegrates, and the enamel organ takes on a bell shape. Odontoblasts within the dental papilla elongate but have not yet produced dentin. The enamel organ's outer layers are defined.
      - Late Bell Stage: This stage involves the secretion of molecules by the enamel organ and dental papilla, leading to the formation of tooth crowns. The Hertwig epithelial root sheath forms, and root dentin, cementum, pulp, and the periodontal ligament develop.
      - These stages mark the progression of tooth development from the early initiation to the formation of the functional tooth.
  - - - Differentiation of ameloblasts.
      - Stages of ameloblast function: morphogenesis, organization, secretion, maturation, and protection.
      - Cell-to-cell attachments and Tomes processes.
      - Matrix synthesis and transport.
      - Enamel rod formation.
      - Enamel knots for coordinating.
      - Incremental enamel growth.
      - Blueprint for crown shape provided by the inner enamel epithelium.
      - Dentinoenamel junction marks the enamel-dentin boundary.
  - - - Odontoblast Elongation: Odontoblasts develop and extend processes.
      - Predentin Formation: Odontoblasts secrete unmineralized predentin, a collagen scaffold.
      - Calcification: Predentin is mineralized with calcium phosphate crystals.
      - Incremental Growth: Dentin is added in layers along the dentinoenamel junction.
      - Dentinal Tubules: Tiny tubules form, contributing to tooth sensitivity.
      - Two-Phase Dentinogenesis: Involves matrix formation and subsequent mineralization.
      - Mineralization: Minerals are added, forming calcified dentin.
      - Daily Rhythm: Dentin forms with a daily rhythm, contributing to dental health.
- - - - Preeruptive Phase: Root development begins, defining the boundary between crown and root. Dental tissues like dentin, cementum, and pulp form.
      - Prefunctional Eruptive Phase: Root continues development and moves through the alveolar bone, aiming to reach the oral cavity. Focus is on positioning.
      - Functional Eruptive Phase: Tooth contacts the corresponding or opposing tooth in the opposite arch.
  - - - Alveolar Bone
      - Periodontal Ligament (PDL)
      - Cementum
      - Gingiva (Gums)
  - - - Pre-eruptive Movements: Random small movements during crown development.
      - Intraosseous Stage: Initial eruption movements after crown development, creating an eruption pathway.
      - Mucosal Penetration: Enamel matrix proteins are released; the junctional epithelium forms during penetration of the oral mucosa.
      - Pre-occlusal Eruption: Eruption pathway is established, and the tooth nears the alveolar crest.
      - Post-occlusal Eruption: Tooth reaches its functional position, and circumferential bone and lamina dura stabilize it.
- - - - Primary cell: Ameloblasts.
        
        Origin: Derived from ectodermal tissue, particularly the dental lamina, during tooth development.
        
        Function: Responsible for enamel formation, producing enamel proteins, and mineralizing the enamel matrix.
        
        Morphology: Columnar cells connected with the dental epithelium's basement membrane.
        
        Differentiation Stages:
        
        Pre-ameloblasts: Present before enamel production begins.
        
        Ameloblasts in the Secretory Stage: Responsible for secreting enamel.
        
        Ameloblasts in the Transitional Stage: Undergo morphological changes during maturation.
        
        Ameloblasts in the Protective Stage: Provide protection for the underlying enamel.
    - - Primary cell: Odontoblasts.
        
        Origin: Differentiate from ecto-mesenchymal cells in the dental papilla.
        
        Function: Production of dentin, a hard tissue supporting and protecting the pulp.
        
        Morphology: Large columnar cells lining the interface between dentin and pulp.
        
        Differentiation Stages: Functional differentiation characterized by the synthesis of type I collagen and non-collagenous proteins, first appearing during the bell stage at 11-12 weeks in utero.