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SLEEP - Coggle Diagram
SLEEP
naps
benefits cognitive, mood, behavioural state etc.
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stages of sleep
stage 1: theta activity, 10ish mins
stage 2: sleep spindles + k complexes, 15 mins
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stage 3/4: SWS, delta 45ish mins - groggy if woken
REM, 20ish mins - paralysis, theta activity
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flip on-off
on = arousal units activated, sleep vlPOA inhibited
off = arousal units inhibited, sleep vlPOA excited
REM on-off
REM = SLD activity, PAG inhibition
NON-REM = SLD inhibition, PAG activity
promote wakefulness
arousal units
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dopamine
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periaqueductal grey, VTA, STN
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orexin
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excitatory effects on LC, raphe, TMN, pontine, VTA, nucleus basalis
ACh
pointine, tegemental nuclei, nucleus basalis = ACh release in cortex
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psychostimulants
issues: anxiety, irritability, akathisia, insomnia
caffiene, nicotine, amphetamines
promote sleep
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adenosine
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during wakefulness: astrocyte glycogen stores are progressively depleted as glycogen decreases, adenosine increases
during SWS: astrocytic glycogen stores are replenished, adenosine is broken down
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CNS depressants
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issues with CNS depressants = psychomotor, cognitive slowing, tolerance, sleep distortion
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