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VAGINA - Coggle Diagram
VAGINA
VAGINAL TUMORS
EMBRYONAL
RHABDOMYOSARCOMA
Malignant mesenchymal proliferation
of immature skeletal muscle
Bleeding grape-like
mass protruding
CHILDS < 4/5 YEARS
Rhabdomyoblast: hallmark→cytoplasmic cross-striations
//spindle-shapped cells Desmin and myogenin ⊕.
From vagina/penis
RARE; Also called
Sarcoma Botryoides
CLEAR CELL
ADENOCARCINOMA
Arises from
vaginal adenosis
Malignant proliferation of
glands with clear cytoplasm
Rare, but feared
DES exposition
SQUAMOUS
CELL CARCINOMA
Usually 2° to cervical SCC
1° vaginal carcinoma rare.
ADENOSIS
Focal persistence of columnar
epithelium in the upper vagina
During development→ squamous epithelium from the lower 1/3 of the vagina (derived from the urogenital sinus) grows upward to replace the columnar epithelium lining of the upper 2/3 of the vagina (derived from the Müllerian ducts).
↑↑ incidence in females exposed to
diethylstilbestrol (DES) in utero
IMPERFORATED HYMEN
Incomplete degeneration of the
central portion of the hymen
If persist
1° amenorrhea
Cyclic abdominal pain
Hematocolpos →bulging and bluish hymenal membrane
NORMAL: Accumulation of vaginal
mucus at birth → self-resolving bulge in introitus
VAGINAL CARCINOMA
From squamous epithelium
lining the vaginal mucosa
Precursor lesion is vaginal
intraepithelial neoplasia (VAIN).
Metastazes:
2/3 upper vagina: Regional iliac nodes (internal iliac)
1/3 lower vagina: inguinal nodes (inguinofemoral)
Related to high-risk HPV
16 & 18 types
Canal leading to the cervix
Mucosa is lined by non-keratinizing
squamous epithelium
Dx Physical exam + Vulvar colposcopy + Biopsy.