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Melanoma - Coggle Diagram
Melanoma
Risk factors
Sun exposure
Fair skin
Periequatorialzone
History
Mole count >50
Dysplastic nevus
FH
Gene mutations
CDKN2A
CDK4
MITF
TERT
ACD
TERF2IP
POT1
MC1R
BAP1
Immunosuppresion
Etiology
UV light
CSD
pathophysiology
4 step model
Mitogenic driver mutation
CDKN2A loss
Escape primary senescence
TP53 mutation
Overcoming apoptosis
BRAF mutation
Immortalization
TERT-p mutation
Oncogenic signalling pathways
MAPK
P13K/AKT/mTOR
WNT/ beta catenin signaling pathway
Clinical
Most common
Female
Lower extremeties
Male
Trunk
Extracutaneous
Evua
anorectal
Upper aerodigestive tract
Sinonasal tract
Leptomeninges