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Clinical enzymology - Coggle Diagram

- - - - Present in plasma in higher conc. than in tissues
      - function in plasma
      - Synthesized by liver
      - Decrease in disease conditions
      - Eg. Clotting enzymes, lipoprotein lipase
    - - Present in tissue at higher conc. than plasma
      - No function in plasma
      - Synthesized in liver, skeletal muscle, heart, brain
      - Increased in disease conditions
      - Creatinine kinase, Alanine transaminase
      - Used to assess cell damage & proliferation ie. Diagnosis of disease.
        Infer location & nature of pathological changes in tissues
- - - - Inc. ALP in last trimester
        Transaminases & CK inc. during & after labour
    - - Inc. AST & bilirubin in neonates
      - Inc. ALP of bony origin in children & elderly
    - - GGT higher in men than women